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Optimal Antibody Purification Strategies Using Data-Driven Models Article

Songsong Liu, Lazaros G. Papageorgiou

Engineering 2019, Volume 5, Issue 6,   Pages 1077-1092 doi: 10.1016/j.eng.2019.10.011

Abstract:

This work addresses the multiscale optimization of the purification processes of antibody fragmentsnonlinear programming (MINLP) models are proposed to minimize the total cost of goods per gram of the antibodypurification process, incorporating the data-driven models.

Keywords： Antibody purification     Multiscale optimization     Antigen-binding fragment     Mixed-integer programming    

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Bioinspired and biomimetic membranes for water purification and chemical separation: A review

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1412-8

Abstract:

•The history of biological and artificial water channels is reviewed.

Keywords： Aquaporins     Artificial water channels     Biomimetic membranes     Chemical separation and water purification    

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Advanced purification and comprehensive utilization of yellow phosphorous off gas

Ping NING,Xiangyu WANG

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 2,   Pages 181-189 doi: 10.1007/s11783-014-0698-1

Abstract: Without appropriate purification and removal, this off gas has potential to cause severe pollution problemsIn this paper, the significance of purification and reutilization of yellow phosphorous off gas are exploredThe principles, processes, and main characteristics of the technologies for purification and reuse ofWe conclude that advanced purification and comprehensive reutilization can be an effective solution for

Keywords： yellow phosphorous off gas     purification     comprehensive utilization    

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Purification of

Y. LIU, M. PIETZSCH, J. ULRICH

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 37-42 doi: 10.1007/s11705-013-1303-z

Abstract: Here a case study of -asparaginase II out of a recombinant is presented. The target protein was obtained by simple cell disintegration and acetone precipitation. The -asparaginase II has been crystallized in three different forms in the following microbatch crystallization. The rod-shaped crystals (~400 μm edge length) were obtained at either 8°C or 22°C after 17 h by addition of PEG . The rectangular-shaped crystals were obtained after further recrystallization of the rod-shaped crystals. The rhombic-shaped crystals formed at 8°C after 12 days when cold ethanol was used instead of PEG . All crystallizations were performed in tris-acetate buffer (50 mmol·L , pH 5.1). By crystallization, the specific activity of -asparaginase II has increased 5-fold. The protein content and the purity of the crystals were evaluated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The more concentrated -asparaginase II out of an extract mixture and the presence of only less minor proteins after crystallization demonstrates that crystallization is an effective and mild method to purify the target protein. The single crystal X-ray diffraction pattern reveals that the crystals are proteins and the X-ray powder diffraction (XRPD) pattern shows clearly that the crystals forming in PEG and ethanol have different crystal structures.

Keywords： protein crystallization     L-asparaginase II     purification    

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A hybrid fuel cell for water purification and simultaneously electricity generation

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 1, doi: 10.1007/s11783-023-1611-6

Abstract:

● A novel hybrid fuel cell (F-HFC) was fabricated.

Keywords： Flow-through field     Hybrid fuel cell     Polyoxometalates     Water purification     Electricity generation    

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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Frontiers of Medicine doi: 10.1007/s11684-023-0996-8

Abstract: Here, we discovered that BGB-A445, a non-ligand-competitive agonistic anti-OX40 antibody currently underdose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependentdemonstrated robust and dose-dependent antitumor efficacy, whereas the ligand-competitive anti-OX40 antibodyFurthermore, BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody.

Keywords： BGB-A445     OX40     agonistic antibody     OX40L noncompetitive    

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Passive antibody therapy in emerging infectious diseases

Frontiers of Medicine doi: 10.1007/s11684-023-1021-y

Abstract: Antibody therapies encompassing convalescent plasma, hyperimmunoglobulin, and neutralizing monoclonalIn addition, the prospects of applying antibody therapy against VOCs was assessed, offering insights

Keywords： SARS-CoV-2     COVID-19     convalescent plasma     hyperimmunoglobulin     neutralizing monoclonal antibodies    

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Pressure swing adsorption/membrane hybrid processes for hydrogen purification with a high recovery

Baojun Li,Gaohong He,Xiaobin Jiang,Yan Dai,Xuehua Ruan

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 2,   Pages 255-264 doi: 10.1007/s11705-016-1567-1

Abstract: The hybrid hydrogen purification processes were simulated using HYSYS and the processes were evaluatedcomparison, a PSA process and a membrane separation process were also used individually for hydrogen purification

Keywords： hydrogen purification     PSA     membrane separation     hybrid process    

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Production of a polyclonal antibody to the VP26 nucleocapsid protein of white spot syndrome virus (wssv

Suchera LOYPRASERT-THANANIMIT, Akrapon SALEEDANG, Proespichaya KANATHARANA, Panote THAVARUNGKUL, Wilaiwan CHOTIGEAT

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 216-223 doi: 10.1007/s11705-012-1289-y

Abstract: The objective of this work was to produce a polyclonal antibody against VP26 and use it as a biosensorprotein (rVP26) was produced in (BL21), purified and used for immunizing rabbits to obtain a polyclonal antibody

Keywords： recombinant protein     polyclonal antibody     label-free biosensor     impedance     white spot syndrome virus (WSSV    

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Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 83-93 doi: 10.1007/s11684-019-0682-z

Abstract: Recently, treatments using cetuximab, also named C225, an anti-EGFR monoclonal antibody, for CRC haveand S492R EGFR accelerate the growth of CRC cells in vitro and in vivo and monoclonal antibodyFurthermore, mAb CH12 showed significantly stronger growth suppression activities and induced a more potent antibody-dependent

Keywords： S492R EGFR ectodomain mutation     colorectal cancer     mAb CH12     immunnotherapy    

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Preparation of hapten-specific monoclonal antibody for cadmium and its ELISA application to aqueous samples

Huan HE, Bo TANG, Cheng SUN, Shaogui YANG, Weijuan ZHENG, Zichun HUA

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 3,   Pages 409-416 doi: 10.1007/s11783-011-0349-8

Abstract: The monoclonal antibody with high level of binding affinity for Cd-IEDTA-BSA and high specificity for

Keywords： cadmium     hapten     monoclonal antibody     enzyme-linked immunosorbent assay (ELISA)    

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Nanofiltration for separation and purification of saccharides from biomass

Xianhui Li, Sheng Tan, Jianquan Luo, Manuel Pinelo

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 4,   Pages 837-853 doi: 10.1007/s11705-020-2020-z

Abstract: Saccharide production is critical to the development of biotechnology in the field of food and biofuel. The extraction of saccharide from biomass-based hydrolysate mixtures has become a trend due to low cost and abundant biomass reserves. Compared to conventional methods of fractionation and recovery of saccharides, nanofiltration (NF) has received considerable attention in recent decades because of its high selectivity and low energy consumption and environmental impact. In this review the advantages and challenges of NF based technology in the separation of saccharides are critically evaluated. Hybrid membrane processes, i.e., combining NF with ultrafiltration, can complement each other to provide an efficient approach for removal of unwanted solutes to obtain higher purity saccharides. However, use of NF membrane separation technology is limited due to irreversible membrane fouling that results in high capital and operating costs. Future development of NF membrane technology should therefore focus on improving material stability, antifouling ability and saccharide targeting selectivity, as well as on engineering aspects such as process optimisation and membrane module design.

Keywords： saccharides     nanofiltration membrane     hybrid membrane process     biomas    

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CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 204-211 doi: 10.1007/s11684-016-0443-1

Abstract: A positive clone of CD176 single-chain variable antibody fragment (scFv) was successfully screened from

Keywords： CD176     Thomsen-Friedenreich antigen     scFv     cancer     therapy     adhesion     metastasis    

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Selection and characterization of eight freshwater green algae strains for synchronous water purification

Jingjing ZHAN,Qiao ZHANG,Momei QIN,Yu HONG

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 3,   Pages 548-558 doi: 10.1007/s11783-016-0831-4

Abstract: The objective of this study is to select and characterize the candidate for synchronous water purificationHQ was the possible candidate for water purification coupled with lipid production.HQ to serve for algae-based synchronous biodiesel production and wastewater purification.

Keywords： freshwater microalgae     biomass production     lipid accumulation     nutrient removal    

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Hybrid energy harvesting systems for self-powered sustainable water purification by harnessing ambient

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 10, doi: 10.1007/s11783-023-1718-9

Abstract: List>

● Energy harvesters harness multiple energies for self-powered water purification

Keywords： Piezocatalysis     Solar energy     Waste heat     Decentralized water treatment     Point-of-use     Nanogenerator    

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Title Author Date Type Operation

Optimal Antibody Purification Strategies Using Data-Driven Models

Songsong Liu, Lazaros G. Papageorgiou

Journal Article

Bioinspired and biomimetic membranes for water purification and chemical separation: A review

Journal Article

Advanced purification and comprehensive utilization of yellow phosphorous off gas

Ping NING,Xiangyu WANG

Journal Article

Purification of

Y. LIU, M. PIETZSCH, J. ULRICH

Journal Article

A hybrid fuel cell for water purification and simultaneously electricity generation

Journal Article

BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Journal Article

Passive antibody therapy in emerging infectious diseases

Journal Article

Pressure swing adsorption/membrane hybrid processes for hydrogen purification with a high recovery

Baojun Li,Gaohong He,Xiaobin Jiang,Yan Dai,Xuehua Ruan

Journal Article

Production of a polyclonal antibody to the VP26 nucleocapsid protein of white spot syndrome virus (wssv

Suchera LOYPRASERT-THANANIMIT, Akrapon SALEEDANG, Proespichaya KANATHARANA, Panote THAVARUNGKUL, Wilaiwan CHOTIGEAT

Journal Article

Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

Journal Article

Preparation of hapten-specific monoclonal antibody for cadmium and its ELISA application to aqueous samples

Huan HE, Bo TANG, Cheng SUN, Shaogui YANG, Weijuan ZHENG, Zichun HUA

Journal Article

Nanofiltration for separation and purification of saccharides from biomass

Xianhui Li, Sheng Tan, Jianquan Luo, Manuel Pinelo

Journal Article

CD176 single-chain variable antibody fragment inhibits the adhesion of cancer cells to endothelial cells

Jiangnan Liu,Bin Yi,Zhe Zhang,Yi Cao

Journal Article

Selection and characterization of eight freshwater green algae strains for synchronous water purification

Jingjing ZHAN,Qiao ZHANG,Momei QIN,Yu HONG

Journal Article

Hybrid energy harvesting systems for self-powered sustainable water purification by harnessing ambient

Journal Article